Beilstein J. Org. Chem.2019,15, 1722–1757, doi:10.3762/bjoc.15.168
peptidylnucleosides with primarily antifungal properties. The stereoselective synthesis of (+)-polyoxamic acid ((2S,3S,4S)-144) was successfully carried out starting with Horner–Wadsworth–Emmons olefination of the aziridine aldehyde (2R,1'R)-6 which provided a 98:2 mixture of trans- and cis-acrylates 69b
Beilstein J. Org. Chem.2016,12, 1765–1771, doi:10.3762/bjoc.12.165
; carbohydrate; peptidylnucleosides; Introduction
Peptidyl nucleoside antibiotics are a class of complex molecules that encompass an extensive array of natural products [1]. The notable structural features of peptidylnucleosides are responsible for their miscellaneous biological activities such as antitumor
, antiviral, antibacterial and antifungal [2]. Peptidylnucleosides in which the sugar part is in the furanose form are common, however, the sugar framework in the pyranose form, with a nucleobase and a peptide linker at either ends, are rare in nature. A few examples of this category are amipurimycin and